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The Rising Tide Of Carbapenem-Resistant Enterobacterales: A Study Focuses On Fecal Carriage And Associated Factors In Admitted Patients

A recent scientific study was conducted with a purpose to ascertain the frequency of fecal carriage of carbapenem-resistant Enterobacterales (CRE) and carbapenemase-producing Enterobacterales (CPE), along with various factors associated with it. Enterobacterales is a family of microbes that generally colonizes the human gut as a normal flora, across all age groups. Of late, resistance has been observed in almost all of these normal flora.

The focal point of this study was the examination of the resistance phenomenon in CRE and CPE. The study was performed in Saint Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia. A total of 384 rectal swabs were collected from different wards of the hospital. The swabs were plated on MacConkey agar and incubated at 37 degrees celsius for 18 to 24 hours under observation. After the incubation period, susceptibility testing and determination of whether the bacterial isolate produced carbapenemase or not were performed using the BD Phoenix™ M50 compact system and the modified carbapenem inactivation method.

The study revealed that overall prevalence of CRE carriage and carbapenemase-producing Enterobacterales in admitted patients was 17.2% and 7%, respectively. It was also found that prior intake of antibiotics significantly increased the prevalence of CRE carriage.

The study concludes that there is a high prevalence of CRE and CPE among admitted patients, due to which the control of CRE and CPE carriage should be prioritized by performing effective screening of the fecal matters of admitted patients.

Applying the best infection prevention practice in hospital settings can also help in coping with this scenario. Understanding the ever-increasing resistance against antibiotics is imperative for healthcare professionals and hospitals to ensure that they are well prepared to treat potential bacterial infections.


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