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Navigating the Threat of Carbapenemase-producing Enterobacterales (CPE): An Exploratory Conversation with Lucas Schulz, PharmD

A surge in Carbapenemase-producing Enterobacterales (CPE) instances, nationwide, is a rising concern for healthcare professionals, particularly due to the prevalence of more difficult-to-treat New Delhi metallo-β-lactamase (NDM) strains. These strains have triggered a shift and challenge in the resistance landscape, having a significant impact on last-line antibiotics. Our conversation with Lucas Schulz, PharmD, medical liaison…

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Understanding the Disproportionate CDI-Related Mortality and the Importance of Infection Prevention Initiatives

A recent national analysis that spanned a quarter of a century, presented at IDWeek 2025, reveals a sharp demographic skewness in deaths related to Clostridioides difficile infection (CDI) in the United States. This discussion unfolds within the parameters of a study conducted using Centers for Disease Control and Prevention (CDC) WONDER mortality data within the…

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The Evolution and Impact of Antibiotic Stewardship in Hospital Medicine: A Comprehensive Overview

The concept of antibiotic stewardship has a far-reaching history in hospital healthcare, dating back to the penicillin era in the 1940s. The rise of antibiotic resistance was first observed with the widespread use of penicillin, with British bacteriologist Mary Barber conducting notable studies on the resistance of Staphylococcus aureus. Antibiotic misuse leading to resistance was…

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The Pivotal Role of Collaboration between Infection Prevention and Antibiotic Stewardship Programs in Healthcare

Entering my 25th year as a clinical infectious diseases pharmacist, I have grown to recognize the essential relationship between my career and the infection prevention department. I have been tasked with leading our antibiotic stewardship program (ASP), which significantly intersects with infection prevention efforts. To effectively tackle the expanding menace of antimicrobial resistance and health…

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Surpassing Necessary Antibiotic Treatment Durations: Analysis Reveals Inconsistency in Hospitals

An examination of data drawn from US hospitals in 2019 underlined that the periods of antibiotic treatment allocated for uncomplicated gram-negative bloodstream infections (GN-BSIs) were extended beyond what was required. This finding demonstrated considerable variation among hospitals, according to research published in Open Forum Infectious Diseases. The study scrutinized information from 4,240 cases of GN-BSI treated…

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Indian Medical Association: Pioneering a Novel Approach to Counter Antimicrobial Resistance

Addressing the accelerating global health issue of Antimicrobial Resistance (AMR), the Indian Medical Association (IMA) has rolled out an innovative, first-of-its-kind globally, 'IMA AMR Smart Hospital' certification initiative. This novel program is aimed at fostering a commitment to superior practices related to antimicrobial usage, in an attempt to reverse the mounting AMR crisis. AMR refers to…

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Infection Prevention Measures and Antimicrobial Stewardship: Impact on Healthcare-associated Infections and Antibiotic Use in Europe

A recent study has underlined the significant implications of healthcare-associated infections (HAIs) in Europe, emphasizing the need for rigorous Infection Prevention and Control (IPC) measures and antimicrobial stewardship. HAIs represent a major public health concern, with an average prevalence estimated at 5.7-6.5%, and an incidence rate of about 3.7 cases per 100 hospital admissions. The issue…

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Stewarding Antimicrobial Practices in Secondary Care: The Case of India’s Lower-Tier Hospitals

Antimicrobial stewardship programs (AMSP) in India are mostly practiced only at tertiary healthcare facilities. However, primary and lower-tier hospitals are usually the first point of contact for patients. This gap underscores the need for antimicrobial control measures in these resource-deficient settings, where prescribing antibiotics and multiple antibiotics is commonplace. There is an urgent need to…

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Unpacking the Revolution in Patient Care: The Impact of Rapid Diagnostics

Creating transformative advancements in patient care, rapid diagnostics are revolutionizing the approach of healthcare systems, playing a critical role in improving patient outcomes and addressing increasing antimicrobial resistance (AMR). Unlike conventional diagnostic techniques that often demand several days to produce results, these innovative diagnostics deliver critical information within minutes. This expeditious feedback allows healthcare professionals…

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