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Insightful Spotlight: The Need for Improved Criteria in Classification of Hospital-Onset Clostridiodes difficile Infection

The existing practice of diagnosing Clostridiodes difficile infection (CDI) as hospital-onset solely on the basis of laboratory identification more than three days after a patient’s admission to a healthcare facility has been deemed inadequate.

According to a recent study, it is clear that a more comprehensive clinical approach is required in identifying true CDI cases, thus ensuring accurate diagnoses and improving patient outcomes. Leading the research study was Dr. Kalvin Yu, the Vice President of Medical Affairs at Beckton, Dickinson and Company (BD). The focus of the study was not only on laboratory test positivity, but also on whether an anti-C difficile antibiotic was being used, which would noticeably indicate clinical recognition of the infection. Dr. Yu emphasizes the importance of refining these criteria given the significant implications of the results; these measures don’t merely contribute to the understanding of CDI, but also hold potential financial ramifications, as they are tied to reimbursement rates provided by Centers for Medicare & Medicaid Services (CMS).

As the capabilities of digital health records advance, it’s critical to ensure the metrics align with the evolving technological advancements to provide the most accurate identification of genuine infections. The investigators of this study call for the classification of hospital-onset CDI to be grounded not only on laboratory identification after three days of admission, but also in conjunction with the decision to treat, thus providing a more intricate model to predict hospital-onset CDI.

Their side-by-side comparison of simple and complex predictive models underscored that an accurate classification should encompass not only the community onset CDI prevalence, the duration of hospital stay, and the rate of ICU admissions, but also hospital-specific factors like bed size and location, and even the hospital’s CDI testing practices.

The outcomes of the study indicate that a multi-faceted, clinically based definition for hospital-onset CDI could be formed from a blend of a positive CDI laboratory test result subsequent to the third day combined with the administration of anti-CDI therapeutic agents. The study also suggests that the model should account for the impact of testing practices in rankings adjusted for the standard infection ratio (SIR). Furthermore, their research found that the community’s CDI onset testing practices didn’t necessarily influence hospital-onset rates, contradicting the belief that large-scale C. difficile testing in the initial days of hospitalization would affect hospital-onset rates.

The researchers advocate for models and metrics that self-adjust based on testing changes and risk-adapt according to the community’s CDI burden to ensure more precise outcomes, particularly for high-risk patients.

Source: https://www.contagionlive.com/view/pursuing-better-metric-for-hospital-onset-c-difficile-infections

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