Surgical site infections (SSIs), a prominent postoperative morbidity source, are frequently linked to multidrug-resistant organisms. In a recent study, researchers focused on isolating and identifying bacterial pathogens from SSIs, and evaluating the corresponding antibiotic susceptibility patterns. Samples were taken from patients who underwent various surgeries across a broad age range, in a tertiary care center. Clinical and laboratory standard institute guidelines were adhered to for the antimicrobial susceptibility testing.
Among the 104 samples, approximately 92% exhibited positive bacterial growth, with Staphylococcus aureus and Pseudomonas aeruginosa as the most common bacteria. The study found notable multi-drug resistance in 33.33% of S. aureus and 37.5% of P. aeruginosa isolates. However, antibiotic susceptibility testing revealed a high sensitivity to linezolid for S. aureus and to ofloxacin for P. aeruginosa, making these two effective agents against the respective bacterial strains.
Evidence provided in this study underscores the critical need for constant antimicrobial resistance surveillance to ensure accurate empirical therapy for SSIs and improve patient outcomes. The research collected from this study could have significant implications on policy-making, prescribing practices, and hospital infection control and prevention measures in healthcare faciltities. Future studies may help expand on these findings, paving a solid way for innovative solutions against multidrug-resistant organisms.
Source: https://bmcmicrobiol.biomedcentral.com/articles/10.1186/s12866-025-04480-9