A retrospective study has shed light on the relationship between the use of antibacterial drugs and bacterial resistance in psychiatric hospitals during the epidemic period. Using data collected from hospital information systems and the National Antibacterial Drug Clinical Application Monitoring Network, this study examines patterns during the 2022 epidemic. The lower antibiotic use rate, usage intensity, cumulative DDDs (Defined Daily Doses), and antibiotic costs in the examined hospital compared to provincially or nationally present a relatively controlled use of antibiotics.
However, the rate of microbiological submission in this hospital is notably higher. The majority of antibiotics used in the hospital were third-generation cephalosporins, penicillins, and quinolones, with cefodizime, amoxicillin, and piperacillin–tazobactam being most commonly used. Bacterial resistance was pronounced with Gram-negative bacteria showing resistance mainly to penicillins, cephalosporins, and quinolones, while Gram-positive bacteria resisted penicillins, macrolides, and quinolones.
With increasing bacterial resistance correlating with higher antibiotic use in psychiatric settings, this impacts treatment outcomes and forecasts for patients. Hence, it is recommended to improvise the monitoring of bacterial resistance and frequently analyze resistance data. This methodology can optimize antibiotic uses in the psychiatric hospitals, ensuring effective treatment and minimal resistance strain development, thereby adding to the healthcare value.
With the ongoing global outbreak of COVID-19, unique challenges are faced by healthcare institutions. Importantly, psychiatric hospitals are necessitated to address both mental and physical health aspects of patients. Amid the rising number of COVID-19 patients, addressing bacterial infections and significant antibacterial treatments is crucial.
Regrettably, the broad-spectrum antibiotics’ widespread use has led to global concerns relating to misuse, ultimately leading to increased antibiotic resistance and multi-drug-resistant strain prevalence. Alas, patients with mental conditions often have self-care abilities deficits, weaker hygiene, and lack self-protection awareness, making them susceptible to bacterial infections. Besides, psychiatric hospitals often operate on a closed management system, and high patient populations in group activities augment infection risks, thereby portraying antibacterial drugs use as crucial in treating psychiatric hospital patients.